Which one of the following statements about imipenem is MOST accurate? A: The drug has a narrow spectrum of antibacterial action B: It is used in fixed combination with sulbactam C: Imipenem is highly susceptible to b-lactamases produced by Enterobacter species D: In renal dysfunction, dosage reductions are necessary to avoid seizures E: Imipenem is active against methicillin-resistant Staphylococci

Which one of the following statements is false? A: Imipenem is often used with cilastatin which can inhibit renal tubular dehydropeptidase Ⅰ in clinic B: First-generation Cephalosporins have higher resistance to beta-lactamases and no nephrotoxicity C: Do not mix aminoglycosides with beta-lactam antibiotics in the same infusion bottle D: Third-generation Cephalosporins have enhanced activity against G- bacteria E: Streptomycin is effective against mycobacterium tuberculosis