• 2022-06-14
    The most relevant measurement in single dose bioavailability studies is
    A: maximum drug serum concentration
    B: time to maximum serum concentration
    C: area under serum concentration –time curve (AUC)
    D: time for peak drug concentration to fall to half
    E: time to appearance of drug in circulation (lag time)
  • C

    内容

    • 0

      What’s more, I could write ____. A: full time B: as a secondary occupation C: with more concentration D: with enough time

    • 1

      Bioavailability of drugs is A: established by FDA regulation at 100% for preparations for intramuscular injection B: 100% for oral preparations that are not metabolized in the liver C: calculated from the peak concentration of drug divided by the dose administered D: important because bioavailability determines what fraction of the administered dose reaches the systemic circulation E: equal to 1 (100%) only for drugs administered by any parenteral route

    • 2

      Efficacy means A: the concentration at which the drug elicits 50% of its maximal effect B: the maximal effect produced by the drug C: the dose at which 50% of subjects exhibit a therapeutic response to a drug D: the dose at which 50% of subjects dies E: the dose at which 50% of subjects exhibit a toxic reaction

    • 3

      The amount of time you can concentrate on something is called your concentration ____. A: width B: span C: depth D: involvement

    • 4

      In the study of pharmacokinetics and bioavailability, LLOQ should be able to determine the drug concentration in biosamples at 3-5 elimination half-lives after dosing or within the range of 1/5 to 1/2 of the Cmax.