The inhibition of carnitine acyltransferase I by malonyl-CoA ensures that the oxidation of fatty acids is inhibited whenever the liver is amply supplied with glucose as fuel and is actively making triacylglycerols from excess glucose.
举一反三
- When fatty acids are readily available as fuels, their breakdown in liver mitochondria yields acetyl-CoA, a signal that further oxidation of glucose for fuel is not necessary.
- The final products of digestion are ? A: fatty acids, starch, glucose B: protein, amino acids, glucose C: protein, fat, carbohydrate D: glucose, amino acids, fatty acids
- Synthesis of fatty acids from acetyl CoA A: need NADPH B: need NAD+ C: produce malonyl CoA in the first step D: occur in mitochondria E: It's the reverse reactions of fatty acid oxidation
- i) The secretion of insulin—which acts to lower the plasma glucose _____—is stimulated by a rise in glucose concentration, for example, and is inhibited by a fall in blood glucose.
- What would be the consequences of inhibiting the carnitine shuttle which transports fatty acids into the mitochondria? A: accumulation of fat droplets in liver and muscle. B: Increase in blood glucose concentration. C: Increase in fatty acid synthesis in the liver. D: Low levels of long chain free fatty acids in the blood.