• 2022-06-19
    The inhibition of carnitine acyltransferase I by malonyl-CoA ensures that the oxidation of fatty acids is inhibited whenever the liver is amply supplied with glucose as fuel and is actively making triacylglycerols from excess glucose.
  • 内容

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      The acetyl CoA required for the synthesis of fatty acids is derive from ( ). A: fat mobilization B: β-oxidation of fatty acids C: degradation of amino acids D: glycolysis E: degradation of glucoses

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      During long term starvation, the energy in brain mainly come from A: glucose oxidation B: ketone bodies oxidation C: lactate oxidation D: amino acid oxidation E: fatty acid oxidation

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      During long term starvation, the energy of brain mainly come from A: glucose oxidation B: fatty acid oxidation C: ketone bodies oxidation D: lactate oxidation E: amino acid oxidation

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      If fatty acid synthesis and β oxidation were to proceed simultaneously, the two processes would constitute a futile cycle, wasting energy. We noted earlier that β oxidation is blocked by malonyl-CoA, which inhibits carnitine acyltransferase I. Thus, during fatty acid synthesis, production of the first intermediate, malonyl-CoA, shuts down β oxidation at the level of a transport system in the inner mitochondrial membrane. This control mechanism illustrates another advantage of segregating synthetic and degradative pathways in different cellular compartments.

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      The direct energy of muscle contraction is A: ATP B: phosphocreatine C: glucose D: fatty acids