Synthesis of fatty acids from acetyl CoA A: need NADPH B: need NAD+ C: produce malonyl CoA in the first step D: occur in mitochondria E: It's the reverse reactions of fatty acid oxidation

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2022-06-19 问题

Synthesis of fatty acids from acetyl CoA A: need NADPH B: need NAD+ C: produce malonyl CoA in the first step D: occur in mitochondria E: It's the reverse reactions of fatty acid oxidation

2022-06-19 问题

The inhibition of carnitine acyltransferase I by malonyl-CoA ensures that the oxidation of fatty acids is inhibited whenever the liver is amply supplied with glucose as fuel and is actively making triacylglycerols from excess glucose.

The inhibition of carnitine acyltransferase I by malonyl-CoA ensures that the oxidation of fatty acids is inhibited whenever the liver is amply supplied with glucose as fuel and is actively making triacylglycerols from excess glucose.

2022-06-19 问题

If fatty acid synthesis and β oxidation were to proceed simultaneously, the two processes would constitute a futile cycle, wasting energy. We noted earlier that β oxidation is blocked by malonyl-CoA, which inhibits carnitine acyltransferase I. Thus, during fatty acid synthesis, production of the first intermediate, malonyl-CoA, shuts down β oxidation at the level of a transport system in the inner mitochondrial membrane. This control mechanism illustrates another advantage of segregating synthetic and degradative pathways in different cellular compartments.

If fatty acid synthesis and β oxidation were to proceed simultaneously, the two processes would constitute a futile cycle, wasting energy. We noted earlier that β oxidation is blocked by malonyl-CoA, which inhibits carnitine acyltransferase I. Thus, during fatty acid synthesis, production of the first intermediate, malonyl-CoA, shuts down β oxidation at the level of a transport system in the inner mitochondrial membrane. This control mechanism illustrates another advantage of segregating synthetic and degradative pathways in different cellular compartments.

2022-06-04 问题