The individuals who have mutations in the LDL receptor that prevent the normal uptake of LDL by liver and peripheral tissues, would result in ( ) A: Lesch-Nyhan<br/>syndrome B: Familial hypercholesterolemia C: Niemann-Pick Type C disease D: Atherosclerosis

A 35-year-old man with severe hypercholesterolemia has a family history of deaths at a young age from heart disease and stroke. Which of the following genes is likely to be defective? A: Apolipoprotein E B: The LDL receptor C: Lipoprotein lipase D: PCSK9 E: LCAT