All of the anti-inflammatory agents reduce the efficacy of thiazides.

Thiazides<br/>and related agents () act on () A: the thick ascending limb of the Henle’s loop B: the proximal convoluted tubule C: the distal convoluted tubule D: the collecting duct E: the late distal tubule and collecting duct

Which of the following drugs is correctly associated with its site of action and maximal diuretic efficacy? A: Thiazides−early distal tubule-7% of filtered Na+ B: Spironolactone−early distal tubule-40% C: Bumetanide−thick ascending limb-15% D: Metolazone−collecting tubule-2% E: All of the above