Nefazodone is prone to be oxidized and metabolized to produce toxic metabolites. Which of the following strategies are used by scientists to optimize its structure and reduce liver toxicity
A: F atom closes metabolic sites
B: Benzene ring replaced with pyrimidine ring
C: Increase metabolic site steric hindrance
D: Introduce metabolizing sites to change metabolic pathways
A: F atom closes metabolic sites
B: Benzene ring replaced with pyrimidine ring
C: Increase metabolic site steric hindrance
D: Introduce metabolizing sites to change metabolic pathways
举一反三
- Which of the following atom of pyrimidine ring is provided by CO2? A: C1 B: C6 C: C5 D: C4 E: C2
- Which of the following can cause metabolic alkalosis? () A: Reduced effective circulation B: lack of chlorine C: Hypokalemia D: An increase in ADH E: Increased aldosterone
- Decreased AB and AB<SB can be seen in: ( ) A: Respiratory acidosis B: Metabolic alkalosis C: Metabolic acidosis D: Metabolic acidosis mixed with metabolic alkalosis E: Mixed acidosis
- Decreased AB and AB<SB can be seen in: ( ) A: Respiratory acidosis B: Metabolic alkalosis C: Metabolic acidosis D: Metabolic acidosis mixed with metabolic alkalosis E: Mixed acidosis
- Metabolic acidosis can increase the GABA concentration in the brain tissue of the patient.