Nefazodone is prone to be oxidized and metabolized to produce toxic metabolites. Which of the following strategies are used by scientists to optimize its structure and reduce liver toxicity
A: F atom closes metabolic sites
B: Benzene ring replaced with pyrimidine ring
C: Increase metabolic site steric hindrance
D: Introduce metabolizing sites to change metabolic pathways
A: F atom closes metabolic sites
B: Benzene ring replaced with pyrimidine ring
C: Increase metabolic site steric hindrance
D: Introduce metabolizing sites to change metabolic pathways
B
举一反三
- Which of the following atom of pyrimidine ring is provided by CO2? A: C1 B: C6 C: C5 D: C4 E: C2
- Which of the following can cause metabolic alkalosis? () A: Reduced effective circulation B: lack of chlorine C: Hypokalemia D: An increase in ADH E: Increased aldosterone
- Decreased AB and AB<SB can be seen in: ( ) A: Respiratory acidosis B: Metabolic alkalosis C: Metabolic acidosis D: Metabolic acidosis mixed with metabolic alkalosis E: Mixed acidosis
- Decreased AB and AB<SB can be seen in: ( ) A: Respiratory acidosis B: Metabolic alkalosis C: Metabolic acidosis D: Metabolic acidosis mixed with metabolic alkalosis E: Mixed acidosis
- Metabolic acidosis can increase the GABA concentration in the brain tissue of the patient.
内容
- 0
代谢源( metabolic source )与代谢库 ( metabolic sink ) :
- 1
Which one of the following conditions can be caused by both hyperkalemia and hypokalemia A: Metabolic acidosis B: Cardiac arrhythmia C: Metabolic alkalosis D: Increased renal tubular K+ excretion E: Increased renal tubular H+ excretion
- 2
Which of the following can occur when PaCO2 is higher than the normal level? A: Primary metabolic acidosis B: Compensated metabolic alkalosis C: Primary respiratory acidosis D: Primary respiratory alkalosis E: Compensated respiratory alkalosis
- 3
The patients with metabolic alkalosis may have mental derangement induced by the increase of γ-GABA.
- 4
The patients with metabolic alkalosis may have mental derangement induced by the increase of γ-GABA. A: 正确 B: 错误