• 2022-06-19
    If fatty acid synthesis and β oxidation were to proceed simultaneously, the two processes would constitute a futile cycle, wasting energy. We noted earlier that β oxidation is blocked by malonyl-CoA, which inhibits carnitine acyltransferase I. Thus, during fatty acid synthesis, production of the first intermediate, malonyl-CoA, shuts down β oxidation at the level of a transport system in the inner mitochondrial membrane. This control mechanism illustrates another advantage of segregating synthetic and degradative pathways in different cellular compartments.
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      Which one of the following is a condition decreased the oxidation of acetyl CoA by the citric acid cycle?

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      The acetyl CoA required for the synthesis of fatty acids is derive from ( ). A: fat mobilization B: β-oxidation of fatty acids C: degradation of amino acids D: glycolysis E: degradation of glucoses

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      The carbon dioxide is primary a product of A: Krebs cycle B: Glycolysis C: Electron transport phosphorylation D: Lactate fermentation E: Fatty acid synthesis

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      Place the following steps in lipid oxidation in their proper sequence. (Note: this is not a complete list of steps)(a) Thiolysis (b) Reaction of fatty acyl-CoA with carnitine (c) Oxidation requiring NAD+ (d) Hydrolysis of triacylglycerol by lipase (脂酶) (e) Activation of fatty acid by joining to CoA (f) Hydration A: (d)→(e)→(b)→(f)→(c)→(a) B: (c)→(f)→(c)→(d)→(a)→(b) C: (e)→(b)→(c)→(f)→(a)→(d) D: (f)→(c)→(b)→(e)→(a)→(d)

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      The synthesis of fatty acids USES carnitine to transport acetyl-CoA from the mitochondria to the cytoplasm.()