Bioavailability of drugs is
A: established by FDA regulation at 100% for preparations for intramuscular injection
B: 100% for oral preparations that are not metabolized in the liver
C: calculated from the peak concentration of drug divided by the dose administered
D: important because bioavailability determines what fraction of the administered dose reaches the systemic circulation
E: equal to 1 (100%) only for drugs administered by any parenteral route
A: established by FDA regulation at 100% for preparations for intramuscular injection
B: 100% for oral preparations that are not metabolized in the liver
C: calculated from the peak concentration of drug divided by the dose administered
D: important because bioavailability determines what fraction of the administered dose reaches the systemic circulation
E: equal to 1 (100%) only for drugs administered by any parenteral route
举一反三
- Bioavailability is: A: Amount of drug that reach the systemic circulation B: Drug metabolized in liver before the drug reaches the systemic circulation C: Drug metabolized in liver after the drug reaches the systemic circulation D: Maximum by rectal route
- The most relevant measurement in single dose bioavailability studies is A: maximum drug serum concentration B: time to maximum serum concentration C: area under serum concentration –time curve (AUC) D: time for peak drug concentration to fall to half E: time to appearance of drug in circulation (lag time)
- Bioavailability < 100% following oral dose administration:( ) A: incomplete absorption B: first pass effect C: both D: neither
- Which of the following routes of administration can achieve the highest bioavailability?() A: Oral B: Intravenous injection C: Intramuscular injection D: Inhalation E: Sublingual
- In<br/>terms of bioavailability, the following statements are true() A: The<br/>amount of a drug absorbed into the bloodstream B: The<br/>total amount of drug in the body at peak concentration C: The<br/>total amount of drug in the body at a steady-state concentration D: The<br/>amount and rate at which a drug is absorbed into the systemic<br/>circulation E: The<br/>amount of drug that passes through the gastrointestinal tract into<br/>the hepatic portal vein